signal & noise

signal & noise

The FDA Just Admitted They Lied to 50 Million Women for 23 Years (And Your Doctor Probably Still Believes It)

How a flawed study, regulatory cowardice & groupthink denied an entire generation of women access to life-saving treatment — and why this reversal gives us hope that truth might be making a comeback.

Tiffany Ryder's avatar
Tiffany Ryder
Nov 15, 2025
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Remember when your doctor told you hormone replacement therapy would basically kill you? Well, funny story...

This week, HHS Secretary Robert F. Kennedy Jr. and FDA Commissioner Marty Makary stood up in front of hundreds of people (including Second Lady Usha Vance, actress/comedian Cheryl Hines, and ME there in blue 🥰) and said what amounted to:

“Oh, our bad. Turns out we’ve been wrong for 23 years.”

It’s not a direct quote.

But also... it’s pretty much spot on.

Here’s what happened.

In 2002, the Women’s Health Initiative published a study (and fueled a media frenzy) that made every woman in America throw her estrogen right in the trash.

The FDA slapped “black box warnings”- their nuclear option- on hormone replacement therapy sternly asserting very, very, VERY bad things would happen to naughty women who didn’t comply.

Prescriptions fell off a cliff. Millions white-knuckled their way through menopause because the alternative was death by breast cancer, obviously.

Except the study was gar…

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